mechanisms of disease Epilepsy
نویسنده
چکیده
N Engl J Med 2003;349:1257-66. Copyright © 2003 Massachusetts Medical Society. pilepsy is one of the most common neurologic problems worldwide. Approximately 2 million persons in the United States have epilepsy, and 3 percent of persons in the general population will have epilepsy at some point in their lives. 1 In recent years, important advances have been made in the diagnosis and treatment of seizure disorders. 2 However, our understanding of the cellular and molecular mechanisms by which epilepsy develops, or epileptogenesis, is still incomplete. In this overview, we highlight some of the prevailing ideas about epileptogenesis by presenting examples of epilepsy syndromes and theories of their mechanisms of origin. Several recent reviews offer more specialized and comprehensive discussions of this topic. 3-5
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